Due to the fact that serious, occasionally fatal, hypersensitivity reactions (including anaphylactic reaction) have been reported in patients previously treated with beta-lactam antibiotics, is necessary before prescribing clen cycle timentin ascertain the absence of a history of similar reactions. In case of allergic reactions should stop using the product and to conduct maintenance therapy, the development of anaphylactic reactions require emergency measures in accordance with the accepted scheme.
Despite the fact that low toxicity Timentin, penicillin antibiotics characteristic, during long-term therapy is recommended to periodically assess renal function, hepatic and hematopoietic.
Increased bleeding observed in patients treated with beta-lactam antibiotics. Such reactions may involve a violation of coagulation, platelet aggregation, and prolongation of prothrombin time (mainly in patients with kidney failure). With the development of bleeding should stop the drug and conduct appropriate therapeutic measures.
In appointing timentin patients who are on a salt-free diet, you need to take into account the sodium content in the product.
Long-term use of the drug clen cycle can lead to the growth of non-susceptible strains of the pathogen.
In patients with impaired renal function dose timentin adjusted in accordance with the recommendations in the section “Dosage regimen with impaired renal function.” In the treatment of mixed infections caused by strains that are sensitive to ticarcillin (including beta-lactamase-producing), no additional administration of other antibiotics.
In order to ensure adequate treatment is necessary to carry out appropriate tests to be susceptible to the antibiotic. However, given the wide range bactericidal activity against Gram-positive and Gram-negative strains, the combination of ticarcillin and clavulanic acid is used as a first line therapy for the treatment of mixed infections until such time as the pathogen is decided. It has been shown to be effective combination of ticarcillin and clavulanic acid, appointed as monotherapy certain severe infections, the treatment of which is a combination of antibiotics commonly used.
The results of in vitro tests showed a synergistic effect of aminoglycosides and combinations with clavulanic acid, ticarcillin in relation to certain strains of Pseudomonas aeruginosa, suggesting the effectiveness of such clen cycle combination therapy (especially for immunocompromised patients). In this case, both drugs should be administered at the recommended therapeutic doses. Upon receipt of the results of tests on the sensitivity of therapy, if needed, should be adjusted.