Tag Archives: clenbuterol dosage

clenbuterol tablets

Clenbuterol Tablets – how to take it for drying and fat burning

Clenbuterol tablets is a medicament for the treatment of bronchial asthma, which has found wide application in fitness and bodybuilding. With the correct intake schedule, clenbuterol significantly accelerates fat burning. However, he has a number of side effects, for which he got on the black list of potent drugs.

Its closest analogue is ephedrine. Unlike ephedrine, clenbuterol is considered less dangerous to the body, but in practice, the side effects from their use are almost identical.

By structure, clenbuterol is a beta-2 agonist, a compound that activates receptors in adipose tissue, and thereby accelerates the breakdown of fat. In addition, clenbuterol increases the synthesis of epinephrine and norepinephrine, which also positively affects weight loss.

Earlier it could be bought at a pharmacy. The recipe for its purchase is conditional, which made clenbuterol one of the most popular fat burners. At the moment to find clenbuterol in pharmacies is extremely difficult, even in private.

Available is clenbuterol in the form of syrup, but its use is unjustified and ineffective for weight loss, so we will not consider this form of the drug.

How does clenbuterol tablets work? Action on the body.

A person loses weight on clenbuterol tablets due to the complex action of the drug:

  • Increases body temperature, which increases caloric intake
  • A huge surge of adrenaline increases the rate of disintegration of fat
  • Pronounced excitation of the nervous system suppresses appetite and increases stamina
  • The process of fat deposition is temporarily blocked
  • Decrease in the breakdown of muscle tissue, tk. the body extracts energy mainly from fat, and not from muscles

The intake of clenbuterol by action resembles a strong pre-training complex. You want to move more, you can not sit still. Training is easier because of an excited nervous system. In addition, the appetite is quenched. You eat less, move more, and are more productive, which in summary simplifies weight loss.

clenbuterol tablets

Principle of action of Clenbuterol

Andrenoreceptors in fat and muscle tissues are of two types – alpha and beta. Excitation of the first group of receptors causes active accumulation of fatty deposits, and the second group, on the contrary, adjusts the work of the organism in such a way that fat begins to be used as a source of energy, the rate of its cleavage increases sharply. Clenbuterol is a beta 2-agonist. It excites andrenoretseptory beta type. Its use triggers a mechanism of biochemical reactions, which enhance lipolysis – the splitting of fats into constituents.

Taking the drug, in addition to burning fat, has a dispersing effect on metabolism, increasing its speed by about 20-30 percent. This makes it possible to obtain one more undisputed advantage in the drying period. Lipoprotein lipase when used Clenbuterol tablets is more active, which prevents the formation of fat in the body. The use of this agent stimulates the function of the thyroid gland to increase the production of hormones, which are fat burners. These properties of clenbuterol for weight loss are excellent in helping to get rid of excess fat deposits.

Produced in tablet form, this preparation becomes an excellent assistant to every athlete during the drying period, it allows to accelerate the metabolism, the secretion of hormones synthesized by the thyroid gland. These and other effects allow you to lose fat deposits against the background of dietary nutrition, implying a deficit of calories consumed.

Misconceptions about the drug Clenbuterol

There are many myths about Clenbuterol. One of the most common misconceptions was the assignment of anti-catabolic drug – anabolic effect. It did not appear from scratch. This was facilitated by conducting tests with animals. However, even huge doses of more than 1 milligram, administered daily to horses, caused similar effects in some individuals and only to a small extent.

Experimental tests of Clenbuterol in animals have nothing to do with the effect of the drug on the human body. The dosage of 1000 μg (1 mg) can be administered to horses. For a person, it is lethal. And even if Clenbuterol has an anabolic effect in large doses, then, unfortunately, for an athlete who uses the drug in small amounts, it does not matter. Therefore, taking a medication for an anti-catabolic effect is devoid of any meaning.

Clenbuterol manifests itself exclusively as a fat burner, prescribed for asthma. It has no other influences, it is advisable to receive it during the drying period. Any other properties attributed to Clenbuterol tablets, if there is, then their influence is negligible, completely imperceptible to the athlete. As a fat burner, on the contrary, Clenbuterol has proved itself only on the positive side. You should not treat it as a “miracle” remedy, which in itself relieves fat deposits. It has a fat-burning effect only if the training and nutrition regime are well-formed.

The drug accelerates metabolism, contributes to the fact that the body begins to use fat as a source of energy, given that it does not receive enough calories along with food. It is necessary to remember about individual characteristics. Properly constructed mode, training, diet sometimes does not allow the athlete to fully experience the effects of Clenbuterol. The rationality of taking these tablets during the drying period allows us to evaluate only the constant monitoring muscles boy of the results achieved. The main thing, in pursuit of the effect, do not forget about caution.

Along with the tablets, Clenbuterol can also be purchased in the form of a syrup. The latter includes sugar. This makes it not the best choice for an athlete. It is better to give preference to tablets.

How to Take Clenbuterol tablets for Fat Burning and Weight Loss

In professional fitness circles the scheme of reception of tableted clenbuterol is popular, based on a gradual increase in dosage.

If you somehow were able to buy clenbuterol tablets, you need to apply the well-known in fitness circles reception scheme, based on a gradual increase in dosage.

Clenbuterol is originally a cure for asthma, as a result of which the drug has a pronounced biological activity. The body tries to quickly minimize the negative effects from its administration bodybuilding site, and speeds up the adaptation, getting used to the chosen dosage of clenbuterol for literally 2-3 days. After getting used the drug does not have the same effect, including does not help to lose weight.

Scheme of reception of clenbuterol:

• Day one – 20 mcg (half a tablet of classical clenbuterol)
• Day 2 – 20 mcg
• Day 3 – 40 mcg
• Day 4 – 40 μg
• Day 5 – 60 mcg
• Day 6 – 60 mcg
• Day 7 – 80 mcg, etc.
• Day 16 – 160 mcg

Will Clenbuterol help to lose weight?

If you lose weight with the current diet and exercise, then you have created a calorie deficit sufficient for losing weight. By adding clenbuterol to this, you can accelerate weight loss, but in return you will damage your health. Many people think that the course of clenbuterol tablets will be only once, and the harm from taking it will be minimal, but this scheme does not make sense, since it will not give a long-term effect.

Clenbuterol intake is justified when preparing for fitness or bodybuilding competitions, when the athlete needs to reduce the percentage of fat, but at the same time keep the muscles for a short period of time – go on stage and show the result.

clenbuterol for weight loss

Clenbuterol for weight loss. Severe fat burner!

Each of us wants to spend less, but to get more results. Most people, when they think about the use of various fat burners, hope that an excellent result can be achieved through the sleeves. Well, today I decided to write for you an interesting material about the use of clenbuterol.

Hello friends! Today we are talking about an interesting and effective fat burner – clenbuterol. In detail I will tell you how to take clenbuterol for weight loss and other interesting practical moments.

This year, for the first time, I used clenbuterol. Never before did I use any fat burners, well, except for coffee, which I really love.

This year I wanted to get a practical case on how to apply various types of fat burners, and how they affect the process of losing weight. I’m sure that the information will be interesting to you, friends.

First I propose to understand what clenbuterol is.

Clenbuterol is an adrenomimetic, i.e. a drug that is used in medicine for the treatment of bronchial asthma.

Clenbuterol DOES NOT RESPOND to the class of anabolic steroids, I repeat, this is adrenomimetic (a medicine for bronchial asthma).

For us, he is not primarily interested in this.

Clenbuterol in bodybuilding is used because of its ability to burn fat due to the excitation of beta-2-adrenergic receptors.

Do not be alarmed, if you have not understood words, the mechanism of action is quite simple.

Clenbuterol for weight loss. Mechanism of action

clenbuterol for weight loss

Clenbuterol for weight loss binds to beta-receptors of the second type in the muscle and adipose tissue of a person. After that, a number of biochemical reactions are triggered, which increase the synthesis of cyclic adenosine monophosphate (cAMP).

Cyclic adenosine monophosphate (cAMP) activates enzymes that mobilize fatty acids from fat cells (adipocytes).

Additionally, clenbuterol, acting on beta-2 adrenoceptors, contributes to the production of adrenaline (a hormone of fear) and norepinephrine (a hormone of rage), which give a fat burning effect.

The secretion of thyroid hormones, which are natural fat burners of the body, also intensifies.

Clenbuterol affects lipoprotein lipase, suppressing its activity, thereby making the process of fat deposition in adipose tissue impossible.

As a result of all the above reactions, the level of basic metabolism increases by 20-30%.

Is the mechanism of action understandable from the point of view of losing weight? Let’s briefly explain again.

In many recent studies, for example, Lee P. of 2015 on formoterol (beta-2 selective agonist), refers to the anti-catabolic effect of clenbuterol, i.e. ABOUT ITS ABILITY TO SAVE THE MUSCULAR TISSUE WITH LOSING.

Experiments in humans in 2015 confirm the ability of clenbuterol for weight loss to retain muscles on drying and accelerate the synthesis of protein, which makes the drug relevant to bodybuilding.

I’m sure you will benefit from my experience with clenbuterol. I’ll describe it in more detail at the end of the article, but for now, let’s look at some of the effects of using this drug.

The positive effects of clenbuterol for weight loss

Based on the studies, the use of clenbuterol has the following positive effects:

  • Burning fat, drying muscles.
  • The growth of strength and endurance.
  • Decreased appetite.
  • Prevention of muscle catabolism.
  • A slight anabolic effect (mild muscle growth).
  • Quite low frequency of side effects (irreversible effects are practically absent).

At the bottom of the article, I will write in detail about my experience and feelings from the use of clenbuterol, I am sure many will benefit from my experience.

One of the well-known authors, Yuri Bombela argues that in large doses (more than 250-300 μg / day) clenbuterol can destroy muscles, contributing to the subsequent hypertrophy of muscle tissue, but this statement is untrue, because neither studies, nor, especially, empirical substantiation was not given. These are just guesses of the author. And to take in such dosages this preparation is simply silly. Later you will understand why.

In 2010, a study was conducted that shows the synergistic effect of the use of clenbuterol on the course of anabolic steroids (if you, of course, use them).

The side effects of clenbuterol

Despite the fact that irreversible side effects of the drug has almost no, you should indicate the most common of them, so that you were aware of:

  • Increased heart rate (can be eliminated with beta-1 blockers, 5 mg of bisoprolol or 50 mg of metoprolol in the morning). Honestly, my heart was beating like mad, at first I even thought about stopping the reception, stopped at a working dosage of 120 mcg.
  • Tremor (trembling). I noticed only in the first days of taking, until about 5-6 days approximately, then gradually fading. Can be eliminated with ketotifen.
  • Sweating. Clenbuterol slightly increases the body temperature, so you are constantly hot, you sweat, and in general a semi-painful condition.
  • Insomnia. If you take clenbuterol late in the evening, then insomnia is possible, but it is eliminated by ketotifenom 1-2 mg per night.
  • Anxiety. Periodically, there is a feeling of excitement. Although it is difficult to notice, especially impressionable people. Eliminated by ketotifen.
  • Increase in blood pressure. Eliminated by beta-1 adrenoblockers, 5 mg of bisoprolol or 50 mg of metoprolol in the morning.
  • Diarrhea (stool disorder). Possible in the first days of taking the drug.
  • Nausea. It is very rare, but it is sometimes possible.
  • Convulsions. Usually with an overdose or at the initial stage of taking the drug. Dangerous thing, because. heart, this is also a muscle. I took clenbuterol during the swimming season, I was afraid that I could reduce something when you were far from the shore. The problem is solved by asparkam or panangin 2-3 times a day during meals.
  • Sometimes, a headache. It is connected, more often, with the increase of arterial pressure.

Contraindications to the use of clenbuterol

Based on the side effects, clenbuterol has contraindications, which MUST be paid attention if you still want to use this drug.

  • Thyrotoxicosis (thyroid disease) and hypersensitivity to the drug.
  • Tachycardia and tachyarrhythmia (rapid heart rhythm abnormalities).
  • Subaortic stenosis of the aorta (non-inflammatory disease of left ventricular muscle, which is characterized by a sharp narrowing of its cavity).
  • Acute period of myocardial infarction.
  • Pregnancy.

clenbuterol for weight loss

Why taking Clenbuterol for weight loss is dangerous for your health

To achieve perfection of forms, people go for a lot, including the use of various medications not intended for weight loss. For the first time to apply clenbuterol for weight loss began athletes, bodybuilders, who believed that he has a fat-burning effect. In 1992, the drug was included in the list of banned for use in professional sports.

But many amateur athletes who do not face doping control, still use this bronchodilator for “drying.” However, not always such steps lead to the desired result, while negatively affecting the state of human health. Everyone should decide for himself: is it worth the victory over a couple of centimeters of “wrinkles” on the waist of problems that can remain for many years.

For those who want to try this drug as a “magic pill” of excess weight, it is worthwhile to get acquainted not only with the opinion of doctors, but also with many-numbered reviews of satisfied and dissatisfied consumers. They can always be found on the web or heard from the instructors’ gyms. In this case, do not forget that all people are different and that that did not bring harm to one, can spoil the health of another individual.

What is Clenbuterol for weight loss?

According to its pharmacological effects, clenbuterol for weight loss refers to bronchodilator drugs. It is produced most often in the form of tablets, but sometimes you can also find clenbuterol syrup (or injection solution). The drug works on the sympathetic nervous system and beta receptors and helps block the attack of asthma in people with asthma.

The intake of the substance stimulates the beta 2 receptors to a large extent (they are associated with the lungs) and very weakly affect the beta 1 receptors (associated with the heart).

Thanks to this, you can stop an asthma attack caused by stress and not affect the functioning of the heart muscle.

Like many other drugs, clenbuterol has been tested on animals. It was then noticed the anabolic action of the substance on the muscles of rats. In addition, by its nature, the drug is a thermogen and promotes fat burning. However, there is no one-hundred-percent confirmation of this information by medicine, since the organisms of animals and humans differ from each other. Moreover, recent studies conducted with the help of bodybuilders have shown that clenbuterol in bodybuilding may well become not only the cause of many health problems, but also lead to loss of muscle mass.

In any case, before taking clenbuterol for weight loss, you should carefully read the instructions and be sure to consult a doctor. At any initial health problems, such experiments can cause unpredictable consequences.

clenbuterol weight loss

Recommendations for use and side effects

If you still want to try the drug as a fat burner and anabolic, it is advisable to follow the following recommendations for admission:

  • dosage for men should be from 2 to 8 tablets per day, and for women – from 2 to 4 tablets (for weight loss);
  • use clenbuterol for weight loss is recommended for 4-6 weeks;
  • accompany reception preferably by a regular measurement of body temperature;
  • To increase the strength, the duration of application can be limited to three to four weeks;
  • in no case can not combine clenbuterol with ephedrine, since this will inevitably lead to heart problems (ephedrine affects the heart-related beta 1 receptors);
  • first gradually increase the dose (from the 1st to the 6th day), then maintain the dosage for 6 days, and then gradually reduce it;
  • If any side effects occur, it is better to stop taking the drug completely.

During the use of clenbuterol, the temperature of the human body can rise to half a degree. That’s why it needs to be measured and if it returns to normal, it means that the drug has stopped functioning. Dosage should not be increased, but it is better to completely stop taking it. You can lower the dose in case when losing weight is not the main goal, but there is a desire to increase muscle strength and endurance.

Clenbuterol (tablets or syrup) can cause a number of undesirable phenomena, which should be noted and in the event of the abandonment of this method to lose a few pounds:

  • tremor;
  • insomnia;
  • excessive sweating;
  • high blood pressure and headaches;
  • nausea;
  • arrhythmia and other heart problems;
  • the appearance of seizures due to loss of potassium.

In addition, the market tips to build muscle for medicines is often “inundated” with fakes. Pills with an indeterminate composition can not only significantly damage health, but also lead to death, but the price of forgery is usually lower than that of the original.

Taking clenbuterol, side effects can be minimized using the optimal scheme or by combining it with other drugs. For this, antihistamines are recommended, including ketotifen. Clenbuterol with ketotifen can be consumed using the following rules:

  • from the 1st to the 4th day you only need to drink clenbuterol;
  • on the 5th day one microgram of ketotifen is added;
  • further to the 27th day of the course, the dose of clenbuterol is increased, and the dose of ketotifen is two micrograms;
  • from the 29th day, a gradual decrease in dosage: clenbuterol to 35 mcg, and ketotifen – up to 1 mcg.

At the end of the course, a two-week break is necessary.

With what to connect clenbuterol for weight loss?

Clenbuterol is really cost-effective to include in courses for drying, with appropriate anabolic steroids. For example, it is interesting to include clenbuterol for weight loss in a steroid cycle, consisting of oxandrolone (oxaver) and trenbolone (simulator), along with stanozolol (stavel). You can also experiment bulking up and connect clenbuterol-ver together with testosterone propionate, boldenone.

To form a dry muscle mass, clenbuterol can be released in conjunction with turinabol. As a result, we get a qualitative set, relief and venousness.

Clenbuterol is to be combined with other fat burners. It can be used together with burners from sports nutrition, thyroxine, ephedrine, yohimbine, methyldrene. You should choose the best combination for yourself individually, because some components can raise the pressure too much.

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clenbuterol in bodybuilding

The effectiveness of Clenbuterol in bodybuilding

Unlike ephedrine, released from the body in a few hours, Clenbuterol in bodybuilding peak activity reaches only the eighth hour after admission and has a fat burning effect lasting for many hours.

The “work” of clenbuterol as a whole does not interfere with the ordinary cycles of the body. This is just one of the facets of the drug, which is becoming increasingly popular among bodybuilders.

Clenbuterol in bodybuilding

Clenbuterol is very widely used in bodybuilding. Here are the main effects of the drug, which made it popular among athletes:

  • Burning fat cells.
  • Drying of muscle mass.
  • Increased body temperature.
  • Suppressing appetite.
  • Anticatabolic effects.
  • Anabolic effects.
  • Losing weight.
  • Emotional mobilization.

Clenbuterol is characterized by a rare and, perhaps, unique quality: the drug allows you to accelerate the rate of building muscle mass and at the same time burn fat tissue. Of course, muscle growth will not be as significant as when taking other medications, and will not go beyond the reasonable.

Clenbuterol in bodybuilding is especially used in women’s fitness rooms. In the United States, there was a time when no female gym could be imagined without female athletes.

The preparation is produced in tablets of 10-20 micrograms, and also in ampoules for injections of 0.016 milligrams and in the form of a syrup. The most convenient and popular form is pills. The standard daily intake of tablets is 5-8 for men and 4 for women. The course of taking pills lasts two weeks.

clenbuterol bodybuilding

Chemically, clenbuterol is an selective beta-2 antagonist that stimulates beta receptors in muscle and fatty tissues. It should be said that clenbuterol is one of the most controversially evaluated drugs of all that bodybuilders use.

For example, there are specialists who claim that the anabolic effect of the drug is absent and clenbuterol is effective only for burning fat.

Clenbuterol in bodybuilding was initially declared a two-day drug half-life, however, is not entirely correct, because the process of destruction of the drug and withdrawal from the body takes place in two phases – short and long (several days).

Long-term exposure how to take clenbuterol on the body has not yet been studied. Studies in animals have produced disappointing results: the drug can lead to apoptosis of the muscles, including cardiac ones. C taking the drug should be very careful and carefully observe the dosage.

How to take Clenbuterol in bodybuilding

From the first to the sixth day the athlete can gradually increase the dosage of clenbuterol by 20 micrograms. On the first day of the course, the dose should be 20 micrograms. From the sixth to the twelfth day, the dosage of the drug can be maintained at 120 micrograms per day.

The next step is a gradual dose reduction. On the thirteenth day, the athlete takes 80 micrograms, the fourteenth – 40. Next, a two-week break. Clenbuterol is better taken in the morning, it will reduce side effects. After reaching a dosage of 120 micrograms, you can start taking clenbuterol twice a day – in the morning and at lunch, breaking the dose into two parts of 60 micrograms.

To reduce the likelihood of side effects (insomnia, nervous and mental overexcitation, palpitation), clenbuterol should be used with ketotifenom – an antiallergic drug.

Here’s how the course of joint reception of clenbuterol and ketotifen looks:

  • From the first to the fourth day, clenbuterol is used according to the procedure described somewhat higher (from 20 micrograms to 80 in four days).
  • On the fifth day, take 100 micrograms of clenbuterol and 1 microgram of ketotifen.
  • From the sixth to the twenty-seventh day of the course, the athlete takes 120 micrograms of clenbuterol and 2 micrograms of ketotifen.
  • The twenty-eighth day is 80 micrograms of clenbuterol, 2 micrograms of ketotifen.
  • The twenty-ninth day is 50 micrograms of clenbuterol and 2 micrograms of ketotifen.
  • The thirtieth day is 35 micrograms of clenbuterol and 1 microgram of ketotifen.
  • Two-week break.

Clenbuterol should be taken in the morning, high dosages should be divided into two doses. Ketotifen is taken in the evening.

An even stronger effect is observed when using a combination of clenbuterol and thyroxine, however, in this case, the risk of side effects increases.

Side effects

The intake of clenbuterol can promote the expansion of the cardiac ventricles (hypertrophy), dangerous forms of heart damage, arrhythmia, cell death and even death. In addition, the use of clenbuterol can cause muscle tremors, blood pressure, increased sweating, headache, insomnia, vomiting and nausea.

The fact is that taking clenbuterol often leads to a loss of potassium by the body and the likely appearance of seizures. To eliminate this danger, clenbuterol should be used in conjunction with panangin and asparcam.

Athletes who have seriously decided to use clenbuterol in training should weigh all the benefits and risks of the drug. Especially dangerous is the prolonged use of clenbuterol, which can lead to dangerous consequences.

Bodybuilders who use clenbuterol should be absolutely sure of the purity and quality of the drug they use. If, despite all the dangerous effects, the athlete decided to use clenbuterol, he should only buy it from well-established sellers.

Clenbuterol in bodybuilding for weight loss (more rigid scheme)

Clenbuterol in bodybuilding causes a general rise in body temperature. Each degree above the norm leads to an increase in the burning of calories by five percent. It is exactly how the fat burner clenbuterol is considered to be the most effective.

Clenbuterol activates the nervous system, leading to the start of lipolysis (the fat burning process). Having the property of inhibiting the activity of lipoprotein lipase, clenbuterol leads to the fact that the deposition of fat cells becomes impossible. Moreover, the drug enhances the production of hormones by the thyroid gland, which also leads to an increase in the fat burning effect.

Due to its unusual properties, clenbuterol is mainly used in bodybuilding for fat burning and drying. Auxiliary drugs – ketotifen and thyroxine.

Clenbuterol is especially popular among athletes preparing for competitions. Especially intensively fat is burned if you combine the drug with the thyroid hormone “Cytomelem”.

For the burning of fat, this dosage scheme is optimal: 5-7 tablets per day for men (about 140 micrograms of the drug) and 80 micrograms for women. Take the drug the athlete starts with one pill, gradually increasing the dose. Schemes for taking Clenbuterol in bodybuilding, designed to burn fat, are quite a lot and they are described in the relevant literature.

Clenbuterol Dosage

clenbuterol dosage for weight lossZidovudine is a thymidine analogue and belongs to the group of nucleoside antiviral drugs. It has strong inhibitory activity against retroviruses, including human immunodeficiency virus .

The infected human cells is phosphorylated by the action of thymidine kinase to azidothymidine triphosphate, which is a substrate inhibitor of reverse transcriptase of retroviruses: the introduction of azidothymidine triphosphate in the synthesized circuit virus , its further formation blocked virus reproduction stops, on which is based the therapeutic effect to reduce concentrations the patient’s blood. Azidothymidine triphosphate Competitive inhibitory activity against reverse transcriptase is approximately 100 times greater than that observed for the polymerase alpha of human cells, thus clenbuterol dosage has no effect on the normal metabolism of the human body.

It was found that low concentrations of zidovudine inhibit many strains of Enterobacteriaceae in vitro, including strains of various species coli (bacteria with resistance develops quickly). Activity against Pseudomonas aeruginosa in vitro has not been established. In very high concentrations (1.9 mcg / ml (7 mmol / L)) suppresses Giardia lamblia, although activity against other protozoa absent.

Clenbuterol dosage is well absorbed from the gastrointestinal tract, maximum concentration (Cmax) in blood is achieved in 30-90 minutes, the bioavailability is 63%. It penetrates the blood-brain barrier (BBB) and is found in the cerebrospinal fluid ( in a concentration of 15-64% of the initial dose.

It penetrates through the placenta, so that its concentration in cord blood is comparable to that in maternal blood. It is found in breast milk. Metabolism occurs in the liver to form a glucuronide which is excreted from the body by the kidneys in the urine.

In patients with impaired hepatic function possible cumulation of zidovudine by decreasing glyukuronirovaniya in the liver.

Data on the pharmacokinetics of zidovudine in pregnant women is limited, as well as in older patients. Children over the age of 5-6 months. Zidovudine pharmacokinetic data are similar to those in adults.

Reception with fatty food reduces the rate and extent of absorption.

When inside designation 200 mg six times daily plasma, the minimum concentration (Cmin) – 0,1 mcg / ml of plasma. It penetrates through the BBB, the concentration in CSF – 24% of the plasma concentration in children. It passes through the placenta (concentration in the tissues of the central nervous system in 13-week fetal – 0.01 mmol / l, which is below the effective antiviral concentration). The volume of distribution clenbuterol before and after in adults and children – 1.4-1.7 l / kg (42-52 l / m). It accumulates in the seminal fluid, wherein the concentration exceed those in serum 1,3-20,4 times, but does not affect the elimination of HIV from semen and therefore can not prevent the sexual transmission.

The average half-life (T?) Of cells – 3.3 hours; serum from adults – about 1 h (0.8-1.2 h), renal failure (creatinine clearance (CC) of less than 30 ml / min) – 1.4-2.9 hours at cirrhosis – varies depending on the severity of liver disease, on average, 2.4 hours; in children aged 2 weeks-13 years – 1-1.8 hours in neonates (whose mothers received zidovudine) -13 hours Renal clearance -. 27.1 mL / min / kg in children – 30.9 ml / min / kg, exceeds KK. In the liver occurs conjugation with glucuronic acid; primary inactive metabolite – 3′-azido-3′-deoxy-5′-O-beta-D-glyukopiranurono-ziltimidin, T? normal kidney function h -1, renal insufficiency – 8 hours at anuria – 29-94 h at cirrhosis – varies depending on the extent of liver failure, on average, about 2.4 hours; excreted by the kidneys and does not exhibit antiviral activity.

In unchanged form excreted by the kidneys by 14-18% in children – 30%; in the form of glucuronides – 60-74% in children – 45%. Not accumulates; in patients with chronic liver failure may be the accumulation of metabolites (conjugates with glucuronic acid), which increases the risk of symptoms of toxic action.

clenbuterol dosage

Indications for use in adults and children over 2 years of HIV infection at the stage of secondary diseases in the stage of acute infection and the primary clinical manifestations at lower less , as well as in the incubation stage.

Pregnant women may be administered with the progression of secondary diseases in HIV infection or when the number of clenbuterol dosage lymphocytes is less than 0.2 x 109%. In other cases, treatment zidovudine can be interrupted before cytomel uk the expiry of the first trimester of pregnancy.

Perenatalnoy Prevention of HIV transmission from an infected mother to child, as zidovudine reduces the risk of intrauterine infection.

Preventing contamination of persons who have received injections and cuts while work with HIV-contaminated material.

Contraindications – Hypersensitivity to the drug; – leukopenia (neutrophil count less than 500 l) – anemia (hemoglobin (Hb) less than 50 g / l); – thrombocytopenia (platelets less than 25 thousand in l.); – Improving aminotransferases and creatinine than 3 times the upper limit of normal; – children under 2 years old.

Precautions: inhibition of bone marrow hematopoiesis, deficiency of cyanocobalamin (vitamin B12) and folic acid, liver failure, older age, obesity, with hepatomegaly, hepatitis or any known risk factors for liver disease. In the treatment of zidovudine such patients should be carefully monitored.

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