Hello everyone, we continue to publish articles in our section on pharmacology, and today our topic will be how to take clenbuterol. Clenbuterol is a drug used in the therapy of bronchial asthma. Since this product simultaneously burns fat, it has become widely used in fitness and bodybuilding for drying and weight loss. Activating the sympathetic nervous system, clenbuterol triggers a mechanism for the breakdown of fats.
Anabolic and anti-catabolic effects of Clenbuterol
With the action of clenbuterol on beta-2-adrenergic receptors of the presynaptic membrane, the release of noradrenaline and epinephrine is enhanced, which have a powerful fat burning effect. Clenbuterol increases the level of basal metabolism by 20-30% of the basal level.
How to take clenbuterol inhibits the activity of lipoprotein lipase, as a result of which fat deposition in adipose tissue becomes impossible. Acting on beta-2-adrenergic receptors of the central nervous system, this drug enhances the secretion of thyroid hormones – the natural body fat burners.
The unique feature of clenbuterol lies in the fact that it is not only a powerful fat burner, but also has a pronounced anti-catabolic effect, protecting the muscles from destruction, which is very important during weight loss and drying in bodybuilding. In studies it was found that the anti-catabolic effect of the drug is due to the blocking of Ca ++ dependent and ubiquitin-proteasome proteolysis.
A new study of 2012 (Francesca Wannenes, Loretta Magni) confirms the ability of clenbuterol to block the mechanisms of muscle atrophy.
Due to the above mechanisms, the drug has a moderate anabolic effect, which is proved in animal experiments and practical application in bodybuilding. Some authors (Yuri Bombela) argue that in large doses clenbuterol may have catabolic effects, but this statement is not true. For this there are no physiological or practical justifications.
Considering the fact that the drug practically does not interact with beta-1-adrenergic receptors, bronchial dilatation and respiratory relief occur, as well as a much lower incidence of cardiovascular clenbuterol side effects, compared to non-selective agonists such as ephedrine.
How to Take Clenbuterol
Rules of admission
The daily dose of clenbuterol is:
- for men – 120-140 mcg;
- for women – 80-100 mcg.
Strict adherence to the rules of admission is required. If this is not done, then a positive result will result in side effects.
The course of admission lasts two weeks. Extend it is not recommended, because in the future the effectiveness of the drug is significantly reduced. After the course, a two-week break is needed, and the course is repeated.
During the course, you need to monitor that the body is supplied in the right amount with proteins, amino acids, vitamins.
The initial how to take clenbuterol cycle should be taken with a gradual increase in the dose in the first week. The scheme of reception looks like this:
- 1-20 μg,
- 2-40 μg,
- 3 – 60 mcg,
- 4 – 80 mcg,
- 5-100 μg,
- from 6 to 12 days – 120 mcg,
- 13 to 80 μg,
- 14 to 40 μg,
- break for two weeks.
This regime contributes to the slow action of the drug without negative consequences. If the amount is more than 50 mcg, the daily dose is divided into two doses: one in the morning, the other in the afternoon.
Combination of clenbuterol with ketotifen
Ketotifen is an antiallergic agent. Thanks to him, the process of drying or losing weight can be accelerated by 10-20%, and the course is extended to eight weeks. The merits of ketotifen include: elimination of mental agitation, ease of falling asleep, and decreased heart rate.
In other words, he fights against the side effects of clenbuterol. The scheme of their joint reception during the month:
- 1 day: clenbuterol 20 mcg.
- 2 day: clenbuterol 40 mcg.
- 3 day: clenbuterol 60 mcg.
- 4 day: clenbuterol 80 mcg.
- Day 5: clenbuterol 100 μg plus ketotifen 1 mg.
- From 6 to 27 days: clenbuterol 120 μg plus ketotifen 2 mg.
- Day 28: clenbuterol 80 μg plus ketotifen 2 mg.
- Day 29: clenbuterol 50 μg plus ketotifen 1-2 mg.
- Day 30: clenbuterol 33-35 μg plus ketotifen 1 mg.
- Break not less than two weeks.
The side effects of clenbuterol
The most common negative effects of the drug are:
- Shivering (about 20% of cases). Ketotifen handles this defect perfectly.
- Increased sweating, especially in men. It is helped by increased intake of sodium (common salt).
- Nausea, anxiety and insomnia often appear in women. This happens in 5-6% of cases and is also eliminated by ketotifen.
Thus, the side effects are not of a critical nature and in most cases are eliminated with an anti-allergenic agent. Other more rare negative manifestations include:
- Palpitation (in 6%). The morning reception of beta-1-adrenoblockers, for example, bisoprolol (5 mg) or metoprolol (50 mg) helps.
- Increased pressure (6%). Also help beta-1-adrenoblockers.
- Diarrhea (at 5%).
- Convulsions (in case of an overdose).
Use of Clenbuterol in Sports
Clenbuterol is banned in sport since 1992. It is determined during anti-doping control for a long time, because it accumulates in adipose tissue and is released during exercise or competition. It is popular among bodybuilders at the level of amateurs who are not covered by anti-doping control. It is believed that clenbuterol has a fat burning effect. One possible way to get clenbuterol into the athlete’s body can be meat, as in some countries (China, Mexico) it is used to increase the weight of fattened animals. In 2012, the Chinese Olympians before the Olympics in London were transferred to a vegetarian diet. Athletes of the Chinese Olympic team have been banned from eating meat before the 2012 Games in London due to the risk of getting into their bodies a prohibited substance – clenbuterol. Violation of the ban is punishable by an exception from the national team.
To receive how to take clenbuterol should be a competent approach. Without compliance, any medicine can be harmful. With a weak cardiovascular system, it is better to abandon it. If you follow the recommended dosage, the worst that can happen is hand trembling and mild headaches. These symptoms quickly go away. Many do not have a negative reaction to the drug at all.
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