Nausea, vomiting and diarrhea. In very rare cases – pseudomembranous colitis.
Moderate increase in what is clenbuterol serum concentrations of aspartate aminotransferase and / or alanine aminotransferase in patients treated with antibiotics ampicillin series. Very rare – hepatitis and cholestatic jaundice.These effects were also observed when other antibiotics of penicillin and cephalosporin series.
On the part of the excretory system
rarely – hypokalemia. Very rarely – hemorrhagic cystitis.
On the part of the central nervous system
rarely – seizures, particularly in patients with impaired renal function and higher doses.
rarely – thrombocytopenia, leukopenia, eosinophilia, decreased hemoglobin levels, prolonged prothrombin time and bleeding time. Perhaps increased bleeding.
pain, burning, redness what is clenbuterol and induration at site of injection and thrombophlebitis at intravenous application.
Overdose Symptoms In case of overdose of the drug in the patient can appear symptoms such as nausea, vomiting, diarrhea. Also may develop fluid imbalance and electrolyte volume. In case of overdose, some patients may develop increased neuromuscular excitability and seizures.
With the development of clinical drug overdose shown symptomatic therapy. In the case of an overdose of ticarcillin and clavulanic acid can be removed from the bloodstream by dialysis.
Interaction with other medicinal products and other interaction
Not recommended combined use with Probenecid. Probenecid decreases the secretion of ticarcillin kanaltsievuyu. The simultaneous use of probenecid leads to slower elimination ticarcillin, but does not affect the excretion of clavulanic acid.
Timentin exhibits synergism with aminoglycosides against a number of microorganisms, including Pseudomonas. In this connection, it is recommended to appoint Timentin combined with aminoglycosides for the treatment of life-threatening infections, especially in patients with compromised immunity. In this case, these preparations are administered separately at the recommended doses.
Clavulanic acid, can cause nonspecific binding of IgG and albumin to the membranes of erythrocytes that leads to false positive results Coombs test.
Like other antibiotics, what is clenbuterolticarcillin may alter the composition of intestinal microflora, leading to a low estrogen reabsorption and as a result, reduce the effectiveness of combined oral contraceptives.
The combined application timentin with aminoglycosides antibiotics should not be mixed in the same syringe, or containers for intravenous infusion systems, as this may reduce the activity of aminoglycosides.
Timentin not stable enough in the infusion fluids containing bicarbonate. Timentin not mix with blood and other protein-like what is clenbuterol fluids such as protein hydrolysates, as well as intravenous lipid emulsions.